Alexander Oraevsky

Bios

Dr. Alexander A. Oraevsky has over 25 years experience managing research and development laboratories in academia and small businesses. He is a pioneer in the field of biomedical optoacoustics. Alexander received his initial training in physics and mathematics from the Moscow Physical and Engineering Institute in Moscow, Russia and obtained a doctorate in laser spectroscopy and laser biophysics from the USSR Academy of Sciences in 1986. He began his pioneering research in the field of optoacoustic imaging, sensing and monitoring in 1987. In 1992, as Whitaker Fellow, he joined the faculty at Rice University, Houston, Texas. He was the Director of the Optoacoustic imaging and Spectroscopy Laboratory at the University of Texas Medical Branch in Galveston, TX and an Assistant Professor at the Department of Ophthalmology and Visual Sciences. In 1998 Dr. Oraevsky founded LaserSonix Technologies, the first company dedicated to commercialization of optoacoustic imaging systems based on the core patent filed in 1996. Presently Dr. Oraevsky is the holder of 7 patents, has published five book chapters and over 150 scientific papers dealing with novel laser technologies applicable in biology and medicine. Before founding TomoWave Labs in 2010, he was Vice President of R&D at Fairway Medical Technologies for 7.5 years. Being business strategist for TomoWave, Alexander continues to lead the research community of biomedical optoacoustics he created by founding and Chairing international conference on “Photons plus Ultrasound: Imaging and Sensing” the largest forum in the area of biomedical optoacoustics held annually under auspices of International Society of Photo-optical Instrumentation Engineers (SPIE). Dr. Oraevsky serves as a Chief Scientific Officer at Seno Medical Instruments on a part-time basis. He also holds an adjunct Professor position at the Biomedical Engineering Department of the University of Houston. Dr. Oraevsky is the recipient of major research grants from NIH, DOD and other sponsors advancing the science of optoacoustics for clinical applications in the areas of cancer diagnostics and therapy.

Education

Ph.D. (1986) - Laser Spectroscopy, Photochemistry and Biophysics, Institute of Spectroscopy, USSR Academy of Sciences, Russia.
M.S. (1980) - Ultrafast Laser Spectroscopy of Biomolecules, Moscow Physical and Engineering Institute, Russia.
B.S. (1978) - Theoretical and Experimental Physics Moscow Physical and Engineering Institute, Russia.

Expertise

Optoacoustic Imaging and Sensing of Tissue and Cells

Optics and imaging of Nanoparticles

Laser Fluorescence Microscopy and Spectroscopy for Medicine

Laser Photochemistry of Biomolecules

Pulsed Laser Ablation of Tissues and Biomaterials

Photothermal, Photomechanical and Photochemical Tissue Effects

Laser Physics, Optical Systems

Selected Publications

1. D.A. Angelov, P. G. Kryukov, V. S. Letokhov, D.N. Nikogosyan, A. A. Oraevsky: Selective action on nucleic acids components by picosecond light pulses. Appl. Phys. 1980; 21(4): 391-395.

2. A.A. Oraevsky, D.A. Angelov, D.N. Nikogosyan: Two-photon photolysis of liquid water and its role in two-step photodecomposition of DNA components in aqueous solution. Sov. J. Quant. Electron. 1980; 7(12), 2573-2577.

3. A.A. Oraevsky, A. V. Sharkov, D. N. Nikogosyan: Picosecond study of electronically excited singlet states of nucleic acid components. Chem Phys Lett 1981; 83(2): 276-280.

4. D.N. Nikogosyan, D. A. Angelov, A. A. Oraevsky: Determination of parameters of excited states of DNA and RNA bases by laser UV photolysis. Photochem Photobiol 1982; 25(5): 627-635.

5. D.N. Nikogosyan, A. A. Oraevsky, V.I. Rupasov: Two-photon ionization and dissociation of liquid water by powerful laser UV radiation. Chem Phys 1983; 77(1): 131-143.

6. D.N. Nikogosyan, A.A. Oraevsky, V. S. Letokhov: Sensitized photodecomposition of solvent under two-step laser excitation of dissolved molecules. Proc.Natl.Acad.Sci.USSR 1985; 283(6), 1425-27.

7. A.A. Oraevsky, V.S. Letokhov, S. E. Ragimov, A. A. Belyaev, B.V. Shekhonin, R. S. Akchurin: Spectral properties of human atherosclerotic blood vessel walls. Lasers in Life Sciences 1988; 2(2):275-288.

8. A.A. Oraevsky, V.G. Omel'yanenko , S.E. Ragimov, V.S. Letokhov: Differentiation of fibrous plaque and normal zone in atherosclerotic vessels: fluorescence and reflectance spectra. Trans. Acad. Sci. USSR 1990; 549(7), 1398-1405.

9. A.A. Oraevsky, S.L. Jacques, G.H. Pettit, I.Saidi, F.K.Tittel, P.D. Henry: XeCl laser ablation of aorta tissue: optical properties and energy pathways, Lasers Surg. Med. 1992; 12(6): 585-597.

10. A.A. Oraevsky, G.H. Pettit, S.L. Jacques, F.K.Tittel, R.A. Sauerbrey, J.H. Nguy, P.D. Henry: XeCl laser induced Fluorescence of atherosclerotic arteries: spectroscopic similarities between lipid-rich lesions and peroxidized lipoproteins, Circulation Res. 1993; 72(1): 84-90.

11. A.A. Oraevsky, R.O. Esenaliev, V.S. Letokhov, A.A. Karabutov, T.V. Malinsky: Studies of acoustical and shock waves in the pulsed laser ablation of biological tissue. Lasers Surg. Med. 1993; 13(4):470-484.

12. A.A. Oraevsky: A nanosecond acoustic transducer with applications in laser medicine, LEOS Newsletter 1994; 8(1): 6-8.

13. A.A. Oraevsky, S.L. Jacques, R.O. Esenaliev, F.K. Tittel: Time-Resolved Optoacoustic Imaging in Layered Biological Tissues", in: "Advances in Optical Imaging and Photon Migration", ed. by Robert R. Alfano, Academic Press, New York, vol. 21, pp. 161-165 (1994).

14. A.A. Oraevsky, S.L. Jacques, R.O. Esenaliev, F.K. Tittel: Pulsed Laser Ablation of Soft Tissues, Gels and Aqueous Solutions at Temperatures Below 100 oC. Lasers Surg. Med. 1995; 18(3): 231-240.

15. A.A. Oraevsky, S.L. Jacques, F.K. Tittel: Mechanism of laser ablation for aqueous media irradiated under confined-stress conditions. J. Applied Phys. 1995; 78(2): 1281-1290.